Find lowest airfare to Mayaguez, Puerto Rico using our powerful search engine. We search over 150 different sites around the world to ensure you find airline tickets to you're looking for. You'll find cheap airfare prices to to Mayaguez, Puerto Rico from your favorite airlines, including United Airlines, American Airlines, Delta Airlines, British Airways, and many more. We also search low-cost airlines, such as Wizz Air, EasyJet, and RyanAir.